Research Spotlight
Research Highlights
Recent work through the unhide® Platform includes new pediatric (ages 2–17) and Spanish-language study components, expanding inclusion across populations and families. The platform now hosts over a dozen published surveys spanning symptoms like mood and cognition, treatments, and daily function, with participation from thousands of individuals across 30+ conditions.
By partnering with researchers at Columbia University, Stanford University, and other organizations, the Brain Inflammation Collaborative is driving cross-disease analyses linking inflammation, neuroimmune processes, and lived experience. These studies are generating real-world data that inform both clinical research and the development of more precise, patient-centered approaches to care.
What Helped, What Didn't
The What Helped, What Didn’t survey collects real-world data on patient-reported treatment outcomes across complex, chronic, and infection-associated illnesses. Participants share which treatments, strategies, or interventions improved—or worsened—their symptoms, creating a clearer picture of what actually works in daily life.
Preliminary results from hundreds of respondents highlight pacing, supplements, and low-dose naltrexone (LDN) among the most frequently reported helpful approaches. Other findings suggest that overexertion and certain medications can worsen symptoms, emphasizing the importance of individualized care.
This growing dataset helps identify common trends across diverse populations while accounting for variability in immune response, inflammation, and comorbid conditions. The study’s findings are guiding future research to better understand why treatments work differently for different people and how biological, behavioral, and environmental factors intersect to influence outcomes.
Understanding How the Brain and Body Shape Mood, Behavior, and Daily Life: Mood and Behavioral Questionnaire
The Mood and Behavior Questionnaire explores how the brain and body interact to influence emotions, focus, and daily life. We are collecting data on how people experience a range of challenges such as anxiety, sleep disturbance, sensory sensitivity, and difficulties with attention, planning, or executive functioning.
These data will help clarify the biological and behavioral pathways that link neuroimmune activity to emotional regulation and day-to-day functioning. By identifying shared patterns across individuals and conditions, this research aims to deepen understanding of how neuroinflammation may contribute to mood and behavioral symptoms observed in both acute and chronic illness.
Three versions of the survey are available:
- Pediatric (ages 7–12): Completed with a parent or guardian
- Teens (ages 13–17)*: Completed with a parent or guardian
- Adult (ages 18+): Designed for independent completion
*dependent on legal age (age of majority) by location
Findings from this study will contribute to ongoing BIC efforts to map the connections between immune signaling, brain function, and quality of life—informing future research collaborations and potential therapeutic targets.
